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We are using cookies to give you the best experience on our site.Cookies are files stored in your browser and are used by most websites to help personalise your web experience. Nowadays, the research interest focuses on cellular and molecular alterations, as results of the complexity of apoptotic process and immune responses acting as initiators and leading to tissue injury. The precise pathogenesis is still unclear, but strong evidences sustain a multifactorial mechanism, based on the interaction of various genetic, epigenetic, environment, hormonal and immune-regulatory factors. In childhood-onset SLE, there are several clinical symptoms more commonly found than in adults, including malar rash, ulcers/mucocutaneous involvement, renal involvement, proteinuria, urinary cellular casts, seizures, thrombocytopenia, hemolytic anemia, fever, and lymphadenopathy.In patients with suggestive clinical findings, a family history of autoimmune disease should raise further suspicion of SLE. The diagnosis of SLE is based on a combination of clinical findings and laboratory evidence.Lupus nephritis is an immune complex GN that develops as a frequent complication of SLE.

As such, dendritic cells, T helper cells, B cells, and plasma cells all contribute to the aberrant polyclonal autoimmunity.

The intrarenal etiology of lupus nephritis involves antibody binding to multiple intrarenal autoantigens rather than the deposition of circulating immune complexes.

Tertiary lymphoid tissue formation and local antibody production add to intrarenal complement activation as renal immunopathology progresses.

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Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder that has a broad spectrum of effects on the majority of organs, including the kidneys.

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