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High to moderate density of neuronal L1 was found in the olfactory bulb, layer V of the cerebral cortex, amygdala, pontine grey, superior colliculi, cerebellar cortex, solitary tract nucleus etc.

Only low to lowest levels of neuronal L1 were found in the hippocampus, grey matter in the caudate-putamen, thalamus, cerebellar nuclei etc. In the adult brain, substantial immunoreactive L1 is detected by western blot and immunohistochemical analyses in the olfactory bulb, cerebellum, cerebral cortex, hippocampus, hypothalamus and spinal cord [].

We examined the overall distribution of L1 in the adult mouse brain by immunohistochemistry using two polyclonal antibodies against different epitopes for L1.

Immunoreactive L1 was widely but unevenly distributed from the olfactory bulb to the upper cervical cord.

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The Panthers are 7-0 for the first time in franchise history, and their quarterback has put himself in the company of Manning, Brady and Rodgers. — Cam Newton had just played three hours and 50 minutes of football in a relentless rainstorm, but the hot shower could wait a few more minutes.The distribution pattern of L1 might provide a basis for understanding its roles in LTP, fear conditioning, and other unknown functions in the brain.For this reason, we studied the total distribution of L1 in the adult mouse CNS using specific polyclonal antisera against full-length L1 and the C-terminal cytoplasmic domain of L1 at the light microscopic level.There was that ‘6’ route in overtime, a dig, which Newton had placed high and inside, where only Brown could catch it. The Panthers’ 29-26 overtime win against the Colts on Monday night improved their record to 7-0, uncharted territory for this 20-year-old franchise and its 26-year-old quarterback.Five seasons after being taken with the first overall pick in the 2011 draft, Newton seems to have fulfilled his promise.




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