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The Global Registry of Acute Coronary Events is a prospective observational study of patients hospitalized with an ACS at 94 hospitals in 14 countries.

The study sample consisted of 5403 patients with ST-segment elevation acute myocardial infarction, 4725 with non–ST-segment elevation acute myocardial infarction, and 5988 with unstable angina.

From the Institut National de la Santé et de la Recherche Médicale Unit 289 (Drs Tallaksen, Ruberg, Verpillat, Brice and Dürr), Fédération de Neurologie (Drs Tallaksen, Fontaine, and Dubois and Mss Guichart-Gomez and Hahn-Barma), Département de Génétique, Cytogénétique et Embryologie (Drs Brice and Dürr), Hôpital de la Salpêtrière; and Département d'Epidémiologie, de Biostatistique et de Recherche Clinique, Hôpital Bichat-Claude Bernard (Dr Verpillat), Paris, France.

Dr Verpillat is now with the Département de Santé Publique, Hôpital Louis-Mourier, Assistance Publique–Hôpitaux de Paris, Colombes, France.

The most frequent form of autosomal dominant hereditary spastic paraparesis is associated with the SPG4 locus, described originally as a pure form of the disease.

Mutations of the SPG4 gene have been increasingly associated with reports of cognitive impairment.

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